Y-chromosomal STR haplotypes in Macedonian population samples

Spiroski et al 2007

"Eleven Y-chromosomal short tandem repeats (STRs), DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439 were typed in DNA samples from Macedonian population (n = 150). The Macedonian population sample has two dominant minimal haplotypes with frequencies > 5% (13,13,30,24,10,11,13,16-18 and 16,13,31,24,11,11,13,14-15). By haplotype extension (DYS437, DYS438, DYS439) both of these minimal haplotypes can be further split up into 4 different, 1-allele step deviant chromosomes, respectively. The frequencies of the 20 most frequent minimal haplotypes in the Macedonian population have been compared with those from populations inhabiting 4 neighbouring geographic regions sampled for the YHRD, i.e. Albania (n = 101), Bulgaria (n = 122), Croatia (n = 150) and Greece (n = 101). The analysis revealed the most pronounced similarities in the minimal haplotype frequency with the Croatian and Albanian samples. The gene diversity for the minimal haplotype was 0.9838, for the 11-locus haplotype 0.9889. One haplotype analysed in this study includes a duplication of the locus DYS19 (alleles 15,16), a type of mutation which has been observed so far with a frequency of about 0.05% in 21,546 individuals in the YHRD (release 10 from February 26, 2004)."